Guggul - the oleogum resin obtained from the Commiphora wightii tree is known for its benefits in lowering and regulating cholesterol levels. Recent research published in the Cardiovascular Drug Review show the therapeutic effects of guggul on the heart.
Guggul's cardiovascular benefits are derived from the multiple pharmacological activities of Guggulsterone the bioactive constituent responsible for guggul's therapeutic effects. The most important are its hypolipidemic, antioxidant, and antiinflammatory activities.
Studies demonstrate that guggulsterone upregulates the bile salt export pump (BSEP). The BSEP removes cholesterol metabolites, bile acids from the liver. The guggulsterone action promotes cholesterol metabolism into bile acids, and is another possible mechanism for its hypolipidemic activity.
Guggulsterone has been found to potently inhibit the activation of nuclear factor-kappaB (NF-kappaB), which triggers inflammatory responses. Repressing NF-kappaB has been proposed as a mechanism of the antiinflammatory effect of guggulsterone
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