How does Diabecon keep sugar levels healthy?

Studies have shown that Diabecon helped lower post prandial blood sugar (PPBS) levels in study subjects. Higher stimulated insulin levels and fasting C-peptide levels have also been reported.

Diabecon has also been shown helpful in preventing sugar-induced cataract. In an organ culture, Diabecon decreased protein carbonyls and prevented the loss of beta(L)-crystallin.

Diabecon has many herbs and minerals in its composition. We will discuss some of the herbal constituents and their mechanisms in keeping blood sugar levels healthy.

One of the best known herbs for blood sugar regulation is Gymnema sylvestre. This herb helps to inhibit sugar cravings, improves insulin production by providing pancreatic support, stimulates enzymes that utilized glucose and inhibits the liver's production of glucose. Gymnemic acids, gymnemasaponins, and gurmarin are the phytoconstituents in Gymnema that cause sweet suppression activity and positive effects on blood sugar homeostasis. Gymnema has also been known to reduce weight, blood cholesterol and triglyceride levels.

Guggul is another herb that helps keep cholesterol levels and blood sugar levels normal. Sugar in blood turns to cholesterol. Guggulsterones help reduce the cholesterol including synthesis of cholesterol in the liver.


Studies have shown that Pterocarpus marsupium, also known as Pitasara help inhibit Dipeptidyl peptidase-4 and have a hypoglycemic action said to be due to an increase in plasma active glucagon-like peptide-1 levels.

More information on Diabecon and its benefits

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References:

Cochrane Database Syst Rev. 2011 Dec 7;(12):CD008288. doi: 10.1002/14651858.CD008288.pub2. Ayurvedic treatments for diabetes mellitus. Sridharan K1, Mohan R, Ramaratnam S, Panneerselvam D.

J Ethnopharmacol. 2005 Feb 28;97(2):397-403. Epub 2005 Jan 18. Effect of Diabecon on sugar-induced lens opacity in organ culture: mechanism of action. Moghaddam MS1, Kumar PA, Reddy GB, Ghole VS.

Biomed Res Int. 2014;2014:830285. doi: 10.1155/2014/830285. Epub 2014 Jan 6. Phytochemical and pharmacological properties of Gymnema sylvestre: an important medicinal plant. Tiwari P1, Mishra BN2, Sangwan NS1.

Pharm Biol. 2014 Feb;52(2):268-71. doi: 10.3109/13880209.2013.823550. Epub 2013 Sep 30. A molecular connection of Pterocarpus marsupium, Eugenia jambolana and Gymnema sylvestre with dipeptidyl peptidase-4 in the treatment of diabetes. Kosaraju J1, Dubala A, Chinni S, Khatwal RB, Satish Kumar MN, Basavan D.

Diabecon and oral hypoglycaemic agents | Control of diabetes with alternative therapy

People with non-insulin-dependent diabetes mellitus (NIDDM), can usually control the disease with a suitable diet and oral hypoglycaemic agents (OHA) like sulphonylurea and biguanides. However after approximately 10-15 years a stage of secondary failure to OHA is reached and most patients require insulin injections.

A double blind, placebo controlled study was conducted to evaluate Diabecon in patients with secondary failure to OHA. Diabecon is a herbal and mineral formulation manufactured by Himalaya Herbals.

40 patients with type 2 diabetes over 30 years of age and with normal body weight were included in the study. All these patients failed to respond to OHA even in maximal doses of combination therapy i.e. glibenclamide 15 mg plus metformin 1000 mg/day for over 3 months despite good diet control and absence of infections, etc.

2 tablets three times a day for 6 months were administered. The fasting and postprandial plasma glucose measurements were made on a monthly basis while the glycosylated haemoglobin, insulin measurements and C-peptide assay were done at baseline, after 3 and 6 months of the trial. A total of 32 patients completed the trial (17 in the drug treatment group and 15 in the placebo group).

In the Diabecon treated group there was a decrease in both fasting and postprandial plasma glucose levels but only the latter reached statistical significance (p=0.004). There was however an increase in the plasma glucose levels in the placebo group. There was a significant decrease in the glycosylated haemoglobin levels from 9.2 ± 1.2% (p=0.04). In the placebo group there was no decrease in HbA1c levels.

In the Diabecon treated group, the plasma insulin and C-peptide levels (both fasting and stimulated) tended to be maintained, or slightly increased even at the end of 6 months. In the placebo group, however there was a decrease in both plasma insulin and C-peptide levels (both fasting and stimulated). This indicates that Diabecon helps to maintain pancreatic beta cell function. Except for one patient each, who complained of gastritis and skin rash, there were no other side effects.