Tuesday, April 28, 2009

Oral Hypoglycemic agents | Diabetes management

Maintaining normal blood glucose levels in Type 2 Diabetes patients is a constant battle. Currently 5 types of oral agents are used in diabetes management which include sulfonylureas, meglitinides, biguanides, thiazolidinediones and alpha-glucosidase inhibitors. These medications are used to treat either one or more of Type 2 diabetes disorders which include insulin deficiency, insulin resistance and increased hepatic glucose output.

The first line of therapy for diabetes management is diet and exercise. When this alone is not sufficient in diabetes control, oral agents are prescribed. However there are downsides associated with almost all five classes of oral hypoglycemic agents (OHAs). Sulfonylureas can cause weight gain and hypoglycemia. The remaining four agents are all very expensive and have side effects such as gastro-intestinal side effects. Thiazolidinediones can cuase weight gain and liver toxicity.

It is often found that the use of a single OHA is not providing satisfactory results. Due to the onset of beta cell degeneration, there is the possibility that insulin therapy will be ultimately required.

Herbal formulations like Diabecon can be used as a valuable adjuvant in diabetes managementHimalaya Diabecon. It can be used in combination with OHAs. It is composed of herbs and minerals and acts somewhat like insulin. It maintains euglycemia and is also said to help repair beta cells. Some of the main herbs in Diabecon are Gymnema sylvestre, Pterocarpus marsupium, Glycyrrhiza glabra, Casearia esculenta, Asparagus racemosus, Commiphora wightii, Momordica charantia and Curcuma longa. It also contains minerals processed in herbal juices that are powerful cellular regenerators. Diabecon Tablets

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